concanavalin a from canavalia ensiformis (jack bean)
Lectin from Canavalia ensiformis (Con A)
CAS: 11028-71-0
Molecular Formula: C15H24
concanavalin a from canavalia ensiformis (jack bean) - Names and Identifiers
concanavalin a from canavalia ensiformis (jack bean) - Physico-chemical Properties
| Molecular Formula | C15H24 |
| Flash Point | 39 °C |
| Water Solubility | Slightly soluble in water and phosfate buffered saline. |
| Solubility | Soluble in water, normal saline or buffer, the solution is clear and free of insoluble substances. |
| Appearance | White to white-like powder |
| Storage Condition | -20°C |
| MDL | MFCD00071069 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
concanavalin a from canavalia ensiformis (jack bean) - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R10 - Flammable R42/43 - May cause sensitization by inhalation and skin contact. R63 - Possible risk of harm to the unborn child R40 - Limited evidence of a carcinogenic effect R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S23 - Do not breathe vapour. S22 - Do not breathe dust. |
| UN IDs | UN 1170 3/PG 3 |
| WGK Germany | 3 |
| RTECS | GK6890000 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 35040090 |
concanavalin a from canavalia ensiformis (jack bean) - Reference
| Reference Show more | 1. Chen Hongwei, Zhong Wenjie, Wu Junwei, et al. Effects of Rabbit Antibacterial Histone on Growth and Cellular Immune Function of Mice [J]. Chinese Veterinary Journal 2014 34(005):798-803. 2. Zhang Bo, Xie Yunliang. Experimental Study on Protective Effect of Total Anthraquinone of Cassia obata on Immune Liver Injury in Mice [J]. Journal of Beihua University (Nature) 2018 19(06):46-49. 3. Wu Yuanguo, Zhao Zhengrong, Zhang Ping, Teng Shiyuan, Zhao Feng, Li Qingqing, Liu Hua. Effect of Compound Dendrobium Granules on Immune Regulation in Mice [J]. China Modern Applied Pharmacy, 2017,34(02):182-185. 4. Zhang Huai, Li Jingui, Zhang Chunlin, et al. Effects of Compound Qizhu Granules on Spleen Lymphocyte Proliferation and Immune Effect of Chick Vaccine in Mice [J]. China Poultry, 2017, 39(008):55-57. 5. Liu Yuxin, Zhao Yu, Wang Xinyu, etc. Study on Immunomodulatory Effect of Modified Guipi Decoction [J]. Jilin Traditional Chinese Medicine, 2020, v.40(03):108-111. 6. Sun Ruikun, Zhang Chaohua, Zeng Shaokui, et al. Optimization of Enzymatic Hydrolysis Process and Immune Activity of Enzymatic Hydrolysate [J]. Journal of Guangdong Ocean University, 2018, 038(003):54-61. 7. Chen Lifang, Wang Huibin, ye Kefan. Effect of Ganoderma lucidum spore powder propolis complex on immune function of mice [J]. Food Industry Science and Technology, 2019, 040(006):294-297,302. 8. Li Wan, Cao Wenhong, Zhang Chaohua, Qin Xiaoming, Gao Jialong, Zheng Huina. Composition and in vitro immune activity of enzymatic hydrolysates of oyster [J]. Food Industry Science and Technology, 2017,38(16):35-42. 9. Wu Yuanguo, Zhao Zhengrong, Zhang Ping, et al. Development of Dendrobium candidum Granules and Evaluation of Immunity Enhancement Function [J]. Food Research and Development, 2019, 40(03):139-143. 10. Xu Wenfeng, liao Xiaoling. Cytocompatibility Evaluation of Hydroxyapatite/Polylactic Acid Particle Composite Biological Scaffold in Vitro [J]. Analytical Chemistry, 2010(12):77-81. 11. Bai Yongquan, Shi Rui, Ru Ningyu, Ma Lirong, Wang Furong, Wang Wenwen, Chen Guo. Remission of acute liver injury induced by concanavalin A in mice and its mechanism [J]. Journal of Henan University (Natural Science Edition),2020,50(05):551-559. 12. [IF = 7.46] Yilin Li et al."An enzyme-free photoelectrochemical sensing of concanavalin A based on graphene-supported TiO2 mesocrystal." Sensor Actuat B- Chem. 2016 Sep;232:226 13. [IF = 6.331] Shupei Zhang et al."TiO2-B nanorod based competitive-like non-enzymatic photoelectrochemical sensing platform for noninvasive glucose detection." J Mater Chem B. 2015 Sep;3(38):7554-7559 14. [IF = 4.22] ding Yu et al."well-oriented bioarchitecture for immobilization of chloroperoxidase on graphene oxide nanosheets by site-specific interactions and its catalytic performance." J Mater Sci. 2017 Sep;52(17):10001-10012 15. [IF = 5.279] Qian Yang et al."Isolation, Identification, and Immunomodulatory Effect of a Peptide from Pseudostellaria heterophylla Protein Hydrolysate." J Agr Food Chem. 2020;68(44):12259-12270 16. [IF = 3.775] Qian Yang et al."Investigation on activation in RAW264.7 macrophage cells and protection in cyclophosphamide-treated mice of Pseudostellaria heterophylla protein hydrolysate." Food Chem Toxicol. 2019 Dec;134:110816 17. [IF = 3.167] Zejun Pei et al."Development of a compound oral liquid containing herbal extracts and its effect on immunity and gastric mucosa." J Food Sci. 2021 Jun;86(6):2684-2699 18. [IF = 3.167] Sen Yang et al."Investigation on the biological activity of anthocyanins and polyphenols in blueberry." J Food Sci. 2021 Feb;86(2):614-627 19. [IF = 3.049] Wan Li et al."The purification and identification of immunoregulatory peptides from oyster ( Crassostrea hongkongensis ) enzymatic hydrolysate." Rsc Adv. 2019 Oct;9(56):32854-32863 20. [IF = 10.618] Xueqin Huang et al."Multifunctional Au nano-bridged nanogap Probes as ICP-MS/SERS dual-signal tags and signal amplifiers for bacteria discriminating, quantitative detecting and photothermal bactericidal activity." BIOSENSORS & BIOELECTRONICS 2022 Sep;212:1 |
concanavalin a from canavalia ensiformis (jack bean) - Introduction
A plant lectin (1ectin) extracted from grains such as concanavalin and pea. It is a tetrameric globulin with a molecular weight of 102000. Each subunit contains 237 amino acid residues, has a molecular weight of 25500, binds one Ca2 + and one Mn2 +, and contains a sugar binding site. It can specifically bind to α-mannose and α-glucose (on cell membrane glycoprotein), and the binding site is required to be the C- 3/C-4 and C- 6 in the six-membed ring of α-D-mannose or α-D-glucopyranose unsubstituted hydroxyl. It can have the greatest affinity with mannodisaccharides and mannotriosaccharides connected by α-1,2 glycosidic bonds. It is a cell-promoting mitogen (mito-gen), which mainly stimulates T lymphocytes, aggregates red blood cells and animal sperm, inhibits tumor cell movement, and prolongs the survival time of heterologous transplantation. An important biochemical and immune research reagent.
Last Update：2022-10-16 17:12:01
concanavalin a from canavalia ensiformis (jack bean) - Reference Information
| use | it is a cell mitogen (mito-gen), which mainly stimulates t lymphocytes, agglutinates red blood cells and animal sperm, inhibits tumor cell movement, and prolongs the survival time of heterologous transplantation. An important biochemical and immune research reagent. Appearance: White lyophilized powder source: Jack beansMolecular weight: 104 kDaSugar specificity: a-Man, a-GlcActivity: Con A reacts with a number of bacterial and animal cells and can distinguish between certain normal and tumour cells. It can initiate cell division (mitogenesis). 0,5-10 μg/ml is required to visibly agglutinate neuraminidase treated erythrocytes.Microorganisms: 90%, OD280nm (ε 1 mg/ml = 1.14), > 95%, essentially salt free Concanavalin A has no blood type specificity, but has affinity for terminal α-D-mannose and α-D-glucosyl residues. The presence of Ca2 + and Mn2 + ions is required to show activity. Concanavalin A dissociates to dimer at pH 6.5 or lower. When the pH is between 5.8 and 7.0, concanavalin A is present as a tetramer; when the pH is higher than 7.0, a higher polymer is formed. Depending on the degree of polymerization, concanavalin A may show mitogenic activity. Succinylation can produce an active dimer that can maintain the dimer form when the pH is higher than 5.6. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | vein-mouse LD50: 50 mg/kg; Abdominal cavity-mouse LD50: 41.5 mg/kg |
| flammability hazard characteristics | combustible, spicy and irritating smoke from the fire site |
| storage and transportation characteristics | warehouse is low temperature, ventilated and dry; Store separately from food raw materials |
| fire extinguishing agent | water, carbon dioxide, dry powder, sand |
Last Update：2024-04-09 20:48:19
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